Platelet-rich plasma (PRP), also known as autologous conditioned plasma, is a concentrate of Platelet-rich plasma plasma protein derived from whole blood, centrifuged to remove red blood cells. Though promoted to treat an array of medical problems, evidence for benefit is mixed as of 2020, with some evidence for use in certain conditions and against use in other conditions. The cost per injection is generally us$ 500 to $2,000 as of 2019. Evidence for benefit of PRP is mixed, with some evidence for use in certain conditions and against use in other conditions, A 2014 Cochrane review of PRP in musculoskeletal injuries found very weak evidence for a decrease in pain in the short term, and no difference in function in the short, medium or long term. There was weak evidence that suggested that harm occurred at comparable, low rates in treated and untreated people,
Similarly, another 2017 review for treating pain on skin graft donor sites found the evidence for benefit was poor.
It has not been shown to be useful for bone healing. A 2016 review of PRP use to augment bone graft found only one study reporting a difference in bone augmentation, while four studies found no difference.